Association of lung function by spirometry with serum ferritin in transfusion-dependent thalassemia patients in a tertiary care centre

Background: β-thalassemia major is an inherited, transfusion-dependent chronic anemia which caused by decreased production of β-globin chains required for formation hemoglobin. Regular blood transfusion most important factors that help in improving the survival patients with TM; however, it leads to iron deposition many organs such as lung. Most studied concerned about effect on lung functions, revealed abnormalities, but limited data were observed. The aim our study was determine pulmonary function abnormalities children thalassemia and assess relation between these overload. Methods: This had included 51 each group, aged 6 18 years (28 males 23 females) TM. All subjected full clinical examination laboratory investigations including complete counts serum ferritin. Pulmonary tests (PFTs) assessed all using spirometry. Results: 31.4% restrictive functions. Spirometer parameters i.e., FEF25-75% (p value≤0.0001) PEFR (%pred) significant difference both groups. no Conclusions: may be considered a site organ damage, alteration expected spite symptoms or normal chest X-ray.